COVID-19 and Personal Protective Equipment-Related Challenges Faced by Pediatric Dentists during patient care: A Qualitative Study

Abstract Objective: To describe the challenges pediatric dentists face while caring for their patients during the pandemic. Material and Methods: A descriptive qualitative study was conducted with purposefully sampled pediatric dentists. Data were collected through in-depth, semi-structured interviews until the content of the collected data reached theoretical saturation. Data were transcribed verbatim, coded, and analyzed using content analyses. Results: Seven participants (four females and three males) between 29 and 50 years participated in the study. Three themes emerged from the analyses: Anxiety and fear; PPE (Personal Protective Equipment) and its impact on care delivery; and 3) Behavior management. Conclusion: Dental care delivery was challenging for pediatric dentists. They experienced high anxiety levels and modified their services according to the recommended guidelines while making accommodations to lessen patients' COVID-19-related anxiety. The additional mandated PPE use affected the communication between the dentists and their patients, affecting their dentist-patient bonding.

ANCHORAGE PREPARATION FOR VARIOUS ORTHODONTIC TREATMENT

There are many kinds of orthodontic movements that make the clinical schedule a genuine test. With the appearance of the skeletal anchorage, it became more straightforward to take care of numerous issues, like anchorage, tipping, interruption among others. The reason for this article was to survey outright anchorage, including signs, implantation site, and any kind of orthodontic element

MSRSGC: A prospective study of heterogenous group atypia of undetermined significance

Context: Many standard books, literatures, and internet described the characteristic lineament of each salivary gland lesion. Nevertheless, there are dozens of disarray, confusion, and unmanageable morphological features regarding proper reporting. To fight with these issues, Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) was introduced in 2018, but still the third category, Atypia of undetermined significance (AUS), poses difficulties for the pathologists and clinicians for a definite interpretation. Aim: The aim is to analyze the risk of neoplasia (RON) and risk of malignancy (ROM) of Milan's category III (AUS) by subdividing into six groups based on cytolomorphology. Settings and Design: The duration of study was from March 2018 to may 2021 with the focus on ROM and RON of all Milan's categories with especial attention on AUS. Methods and Material: Result of total 329 Fine Needle Aspiration Cytology of salivary glands was categorized according to MSRSGC. On the basis of cytomorphology, further subtyping of AUS and its cytohistopathology correlation was done. The ROM and RON of each subtype was analyzed. Statistical Analysis: All data were calculated by existing formulas. Results: Out of 329 aspirates, 24 (07.29%) cases belong to AUS with availability of histology in 13 (54.17%) cases. RON and ROM was 84.62% and 53.85%, respectively. Cases of lymphocytes with nuclear atypia (L-NA) was the most prevalent (29.17%). The RON were 60.00%, 68.57,% 84.62%, 94.87%, 87.50%, 100%, 100% and the ROM were 20.00%, 11.42%, 53.85%, 05.13%, 43.75%, 83.33% and 100% in each Milan's categories I, II, III, IVa, IVb, V, and VI, respectively. ROM was the highest in cystic fluid with nuclear atypia (C-NA) (100.0%), followed by basaloid cells (75%), L-NA (66.675), and SC (50%), but ROM was zero in NA and oncocytic cells. Conclusions: Subgrouping of AUS helps to dissipate the muddiness and provide more exact and reproducible diagnostic and prognostic tool.

Clinico - pathological profile of Adenoid Cystic Carcinoma of the Lacrimal gland - A Retrospective Study at Tertiary Cancer Care Hospital, Punjab

Background: A retrospective study conducted in the department of radiation oncology to review the management aspects of the adenoid cystic carcinoma of the lacrimal gland and identify the outcome and corelation of the recurrence pattern with pathological and clinical findings. Methods: Data of 10 patients of adenoid cystic carcinoma of the lacrimal gland treated over a period of six years were reviewed with respect to presentation, treatment received , end points and outcome. Results: All of the 10 patients underwent surgery followed by adjuvant radiation therapy. Five patients received adjuvant chemotherapy . Eight (80%) patients were alive at a median follow up of 2 years. Five ( 50%) patients withou t evidence of disease and 3 patients with the disease. One patient developed scalp metastasis during the course of radiation therapy and another one developed lung metastasis. Conclusion: Ad enoid cystic carcinoma of the lacrimal gland is a rare neoplasm wi th aggressive outcome. It is often treated with surgery and adjuvant radiotherapy and needs long follow up.

Clinical Usefulness of Cancer Markers in Cancer

Background: Objectives: Cancer is the uncontrolled growth of abnormal cells anywhere in a body these cells can infiltrate normal body tissues of body. The definitive diagnosis of cancer being histo - pathological examination of tissue. The measurement of tumor markers is currently one of the most rapidly growing areas in laboratory medicine and is helpful in differential diagnosis of tumor type in metastatic deposits and also during follow - up evaluations. Methods: Advanced Cancer Institute is a tertiary care cancer institute in Mal wa region of Punjab, old cases with proven history and in the advanced stage of disease, measurement of tumor markers in them is a very important tool for their evaluation of treatment outcome and in staging, emphasis of our study is to highlight and to encourage tumor marker assays for early diagnosis of cancer by checking baseline levels in healthy and in high risk population for screening for the presence of cancer. Results: The Study was carried out Department of Microbiology, Total of 300 Blood Samples were checked in Automated Immune Analyzer (Biomeriux) with different panels of Tumor markers (PSA,AFP,CEA19.9,CA - 125,CA15.3)Kits available in our Lab. of commonly diagnosed cancer. Conclusion: Focus has to be directed towards identification a nd proper use of suitable tumor markers which may prove to be an invaluable tool to early detect the deadly disease in mankind and not to use markers only as a prognostic indicator in proven cases.

Goal-Directed Fluid Therapy Based on Pulse-Pressure Variation Compared with Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: A Randomized Controlled Trial

Methods@#Sixty adults (18–70 years) patients undergoing complex spine surgeries at Siriraj Hospital, Mahidol University, Thailand were enrolled. Patients were allocated to two groups (30 patients in each) using computer-generated randomization. Intraoperative fluid and vasopressor were administrated via either GDT or standard care. The GDT algorithm used PPV and fluid protocol as the primary tool to guide hemodynamic management. The incidences and episodes of perioperative hypotension were measured as the outcomes. @*Results@#Fifty-seven patients were analyzed (three patients in the GDT group were excluded). The baseline characteristics and surgical procedures of the two groups did not differ significantly. The prevalence of intraoperative hypotension was 80.0% for the control group and 66.7% for the GDT group (p=0.25). Two episodes (1–3) of intraoperative hypotension occurred in the control group, and one episode (0–3) occurred in the GDT group; the difference was not significantly different (p=0.57). The intraoperative blood transfusion requirements and postoperative complications were similar in both the groups. In the subgroup analysis, patients with intraoperative hypotension exhibited a higher incidence of postoperative bowel dysfunction. @*Conclusions@#PPV-guided GDT and fluid protocol, as compared with standard practice, did not show significant advantages with respect to intraoperative hypotension, blood transfusion, or postoperative complications in patients undergoing complex spine surgery in the prone position.

Yoga nidra practice shows improvement in sleep in patients with chronic insomnia: A randomized controlled trial

BACKGROUND Yoga nidra is practised by sages for sleep. The practice is simple to use and has been clearly laid out, but its role in the treatment of chronic insomnia has not been well studied. METHODS In this randomized parallel-design study conducted during 2012–16, we enrolled 41 patients with chronic insomnia to receive conventional intervention of cognitive behavioural therapy for insomnia (n=20) or yoga nidra (n=21). Outcome measures were both subjective using a sleep diary and objective using polysomnography (PSG). Salivary cortisol levels were also measured. PSG was done before the intervention in all patients and repeated only in those who volunteered for the same. RESULTS Both interventions showed an improvement in subjective total sleep time (TST), sleep efficiency, wake after sleep onset, reduction in total wake duration and enhancement in subjective sleep quality. Objectively, both the interventions improved TST and total wake duration and increased N1% of TST. Yoga nidra showed marked improvement in N2% and N3% in TST. Salivary cortisol reduced statistically significantly after yoga nidra (p=0.041). CONCLUSION Improvement of N3 sleep, total wake duration and subjective sleep quality occurred following yoga nidra practice. Yoga nidra practice can be used for treatment of chronic insomnia after supervised practice sessions.

A comparative evaluation of bone marrow biopsy and bone marrow aspiration in different haematological condition with special reference to leukaemia and lymphoma

Background: For diagnosis of haematological disorders there are three modalities to examine bone marrow, bone marrow aspiration cytology (BMA), bone marrow imprint (BMI) and bone marrow biopsy (BMB). BMA gives cytological picture; BMI also gives cytological picture but cells are less in number and BMB gives cytological as well as architectural picture. BMA alone may not be sufficient to reach diagnosis therefore the present study was undertaken to compare the above modalities. The study was conducted with the aim to perform cytomorphological evaluation of bone marrow in various haematological disorders with special reference to leukaemia and lymphoma and to compare bone marrow aspiration smears with bone marrow trephine biopsy.Methods: The present study was conducted in department of pathology, LLRM Medical College, Meerut inpatients attending the outpatient department and in-patient department of pediatrics and medicine of SVBP Hospital attached to LLRM Medical College, Meerut, over a period of one year i.e. from March 2018 to May 2019. A detailed clinical history, physical examination and laboratory examination of all the cases was done.Results: Out of 50 cases, maximum number of cases were of anemia 26/50 (52%) followed by leukemia 17/50 (34%), lymphoma 5/50 (10%), multiple myeloma 1/50 (2%), myelofibrosis 1/50 (2%), leishmaniasis 1/50 (2%) and idiopathic thrombocytopenic purpura 1/50(2%). BMA smears were compared with biopsy and concordance and discordance was established. The overall diagnostic accuracy of aspiration was 94%.Conclusions: Bone marrow examination is a safe, quick easy and cost-effective procedure with very less patient discomfort. BMA shows better cellular details when compared to BMI and BMB. BMB is diagnostic investigation in dry tap cases like aplastic anemia, myelofibrosis, myelodysplastic syndrome and metastatic tumors. In present study, concordance between BMA and BMB was seen in majority of the cases and diagnostic accuracy was 94% study concludes that bone marrow aspiration cytology and trephine biopsy complement each other and should be performed simultaneously for complete bone marrow work up and evaluation.

Quality of life, perceived stress and caregiver burden in mothers of children with childhood psychiatric disorders in Kerala, India

Background: Common childhood psychiatric problems like attention deficit hyperkinetic disorder (ADHD), Pervasive developmental disorder (PDD) and learning disability (LD) often co-exists with each other and form a constellation of behavioural manifestations that require extra attention from the caregivers. Having a differentially-abled child is challenging and most parents have to learn to restructure their lives around that of the child. There is a difference in the attitudes of both the parents as far as parenting a disabled child is concerned. Mothers often shoulder the primary caregiving role however the psychological costs borne by women go unrecognized. The study aims to assess the care giver burden (BOC) and perceived stress (PS) and quality of life (QOL) in mothers of children with ADHD, PDD and LD.Methods: It was a cross-sectional study with 336 child mother pairs. The mothers were asked to rate their burden and stress symptoms on the perceived stress scale and Burden of care scale. The mothers were also asked to rate their quality of life on the quality of life scale.Results: The mean PS score was highest in the PDD group. The mean BOC was lowest in the LD group. The QOL score was highest in the LD group.  There is statistically significant difference in the PS, BOC and QOL scores among the three groups.Conclusions: There is a hidden lacuna of psychological stress in mothers of children with common psychiatric problems. The study also establishes that these mothers have poorer quality of life. It is necessary to address these psychological issues of the mother at every visit and equip them with coping strategies so that they can look after both themselves and their special needs child.

Denture Adhesives - Knowledge and Tradition among Denture Wearers in Western Maharashtrian Population - A Survey.

Denture adhesives play a vital role in retention of complete dentures, wherever indicated. Dentists need to know about denture adhesives to be able to identify those patients who actually need them and to be able to educate them about the advantages, disadvantages and correct use of these products. The aim of the study was to evaluate the knowledge about denture adhesives among complete denture wearers indicated for use of denture adhesives visiting Dental Colleges in Western Maharashtra. METHODSThe study was conducted on 300 completely edentulous patients with conventional complete dentures indicated for use of denture adhesives. RESULTSPatients (n= 300) who were wearing ill - fitting complete dentures and required use of denture adhesives were selected, their response about knowledge was assessed by questionnaire survey and those who knew about it were instructed to demonstrate the application of denture adhesive to the intaglio surface of complete denture. 34.7% (n1= 104) of the total subjects (n= 300) had heard about denture adhesives. Out of these 104 subjects, 69.2% (n1= 72; CP= 24%) had used and 77.8% (n1= 81; CP= 27%) knew when to use denture adhesives. Out of 72 subjects who had used denture adhesive, only 30.5% (CP= 7.3%) could demonstrate the adequate technique to use denture adhesive. CONCLUSIONSKnowledge about use of denture adhesives for those who are in need per se has to be spread along with right technique of its use. The indication of its use, and correct technique/techniques of application, should be taught to the patients who demand the use of denture adhesives.

Evaluation of Selection of Various Treatment Modalities Chosen by Subjects for Replacing Single Missing Tooth - A Questionnaire Survey in Western Maharashtra Population.

This survey was done to evaluate awareness of various treatment modalities forreplacing single missing tooth among the people of western Maharashtra. Wewanted to assess gender wise awareness of patients regarding fixed dentalprosthesis as a treatment modality for replacement of missing tooth.METHODSThis cross-sectional study was done on 150 subjects visiting the dental college usinga self-administered structured questionnaire. The questionnaire was pre-testedthrough a pilot survey. Data was evaluated using version 16.0 of the SPSS. ChiSquare test and ANOVA were used as test of significance at p < 0.05.RESULTSOut of 150 subjects, 87 were males and 63 females. Around 64% of the subjectswanted to replace missing tooth due to difficulty in masticatory function; yet 14%knew the importance of aesthetic and speech as well. All subjects preferred fixedprosthesis for replacement of missing tooth, but higher cost of the procedure andfear of surgical trauma were the main factors for not undergoing implant treatment.Dental professionals were the main source of information about different treatmentprocedures followed by media.CONCLUSIONSThere is a strong level of awareness among the subjects about the fixed treatmentprocedure, but more than half of the subjects did not have knowledge about theimplants. It also revealed the need to provide the subjects with more knowledgeabout this treatment modality. Dental awareness is therefore necessary in order tocultivate a positive attitude towards dental implants amongst the community

Comparison of Efficacy of Oral and Intravenous Anti-Hypertensive Drugs in Eclampsia- A Randomized Trial.

Eclampsia increases the risk for both mother and foetus. The treatment aims to quickly bring about smooth reduction in blood pressure to levels that are safe for both, but avoiding any sudden drops, that may in themselves cause dizziness or foetal distress. Hence, this study was conducted to compare the efficacy of anti-hypertensive drugs in eclampsia.METHODS80 eclampsia patients were randomized into two groups: one received oral nifedipine and other intra-venous labetalol. Nifedipine group orally received 10 mg initially with repeated doses of 20 mg every 20 minutes up to maximum of 5 doses or until the therapeutic goal was reached. The other group received intravenous labetalol 20 mg initially followed by escalating doses of 40, 80, 80, and then 80 mg every 20 minutes until therapeutic goal was achieved or for a maximum of 5 doses. Once the therapeutic goal was reached, blood pressure was measured every 20 minutes till delivery.RESULTSMean time required to reach therapeutic blood pressure goal in nifedipine, and labetalol group was 45 ± 22.98 and 59.5 ± 25.41 minutes respectively. Total dose requirement was 1.65 ± 0.57 and 2.17 ± 0.74 mg respectively. The differences between two groups were significant. There was difference in urine output between the two groups as well. In the initial two hours, there was increased urine output in nifedipine group though it was statistically not significant. After two hours till 48 hours, this increased urine output in the nifedipine group was significant (p value 0.001).CONCLUSIONSnifedipine achieved the therapeutic blood pressure goal more rapidly than labetalol.

Dentigerous Cysts of Maxillofacial Region- A Retrospective Clinico- Pathological Analysis of Patients at a Tertiary Care Centre in Central India.

Dentigerous Cyst (DC) is a common type of cyst encountered in oral cavity. These types of cysts are usually found covering the crowns of unerupted teeth and expand in size due to collection of cystic fluid in the region of dental follicle. They can be treated by marsupialisation or enucleation of the lesion based on the involvement of the lesion with the adjacent structures. We wanted to analyze the demographic distribution, clinical, and radiographic features of DC cases reporting to the dental department at NSCB Medical College, Jabalpur (M.P.).METHODSA retrospective study of clinical, radiographic presentation and management of 13 cases of DC attending OPD of Department of Dentistry and treated by enucleation and marsupialization, at Netaji Subhash Chandra Bose (NSCB) Medical College at Jabalpur (M.P.) from July 2016 till December 2017 was conducted.RESULTSOut of 13 cases 8 patients (61.53%) were males and 5 (38.46%) were females. Wide variation in age was seen (14-47 years). 8 (61.53%) patients had a lesion in mandible and was most commonly associated with mandibular third molar which was encountered in 5 cases (38.46%). Most common presenting symptom was a swelling which was found in 76.92% patients. 9 cases (69.23%) were treated with enucleation and marsupialisation was used to treat 4 cases (30.76%).CONCLUSIONSA male: female ratio of 1.6:1 was reported showing a slight male dominance. DC most commonly involved unerupted mandibular third molars. The prognosis of patients treated with enucleation and marsupialisation is satisfactory.

Cord lipid profile comparison of newborns of hypertensive mothers

Background: To compare the cord blood lipid profile of 100 newborn babies born to hypertensive (Group A) and normotensive mothers (Group B).Methods: Total 100 newborns were taken, 50 born to hypertensive mothers and 50 to normotensive mothers. 5ml umbilical venous blood was collected, after clamping the cord, from placental side of the cord and sent to laboratory for centrifugation. Serum was analysed for lipid profile by spectrophotometry by siemens dimensional Rxl- Total Cholesterol, Triglycerides, High density lipoprotein and Low density lipoprotein and Very low density lipoprotein. Comparison of the cord blood lipid levels in both the groups was done.Results: Cord blood lipid profile was deranged in newborns of hypertensive mothers with Cord TC, TG and LDL being statistically significantly higher than the mean reference value and 95th centile. Cord blood of term newborns of hypertensive mothers had Cord TC TG and LDL being statistically higher whereas only Cord TC being statistically higher in preterm neonates of hypertensive mothers.Conclusions: Cord blood lipid levels were significantly deranged in newborns of hypertensive mothers. This helps us in providing the target population at risk and cord blood lipid profile of newborn serving as an indirect guide for lifestyle modifications and helping in early intervention and prevention of future coronary heart disease.

Comparison of determinants of morbidities of late preterms and terms

Background: To compare the determinants of neonatal morbidity in late preterms and terms.Methods: A total of 100 live late preterm (34-0/7 to 36-6/7 weeks) and 100 term infants (37-0/7 to 41-6/7 weeks) admitted in sri guru ram das institute of medical sciences and research were randomly selected to participate in this case control study. The study group include 100 neonates within gestation age of 34 0/7 to 36 6/7 weeks. Equal number of terms between 37 0/7 to 41-6/7 gestation age was taken for comparison. The maternal history including both antenatal and natal history as well as new-born profile was taken.Results: Maternal risk factors have been found to be the major determinants of morbidity in late preterms with PROM (p<0.0001), sepsis and hypertension being significant contributors. Respiratory distress, neonatal jaundice, sepsis has been found to be major morbidity factors in late preterms. The average duration of admission was higher in late preterms than terms.Conclusions: Late preterm infants have higher risks for acute metabolic complications, mortality and long-term disabilities as compared to term infants. Morbidities like respiratory distress, neonatal jaundice, sepsis, hypoglycaemia and hypothermia are more in late preterms due to their immaturity. The risks associated with late preterm birth suggest the need for refinement of obstetric paradigms to extend pregnancy duration if benefits outweigh risk to fetus and mother. There is need to make obstetricians and families aware of complications pertaining to late preterm birth and improving surveillance of high-risk pregnancies.

A prospective study on maternal near miss cases at a tertiary care hospital

Background: Pregnant women’s health status is not only reflected by mortality indicators alone hence the concept of Severe Acute Maternal Morbidity (SAMM) is appropriate for present health providing system. It helps to evaluate the quality of obstetric care in a particular institute. The main objectives of the study were to find a) Incidence of MNMM; b) Disorders underlying MNMM; c) Socio-demographic variables among MNMM; d) Facilities and skills needed to handle these near miss situations.Methods: A prospective hospital-based study was conducted in the department of obstetrics and gynaecology, Gauhati Medical College and Hospital, Guwahati during the period 1st June 2018 to 31st May 2019. Cases were identified based on maternal near miss operational guidelines December 2014.Results: Out of 16222 live births, 241 near miss cases were identified during the study. The maternal near miss incidence ratio is 14.86 per 1000 live births. The maternal near miss to maternal mortality ratio is 2.025. Most common cause of MNMM is hemorrhage (48.54%) followed by hypertension (19.5%), anemia (13.28%), sepsis (10.37%), cardiac dysfunction (6.2%), liver dysfunction (0.83%), renal dysfunction (0.83%) and respiratory dysfunction (0.41%).Conclusions: The large magnitude of MNM cases may be attributed to improper management of obstetric emergencies at the referring hospitals, poor referral practices, inefficient transport system, limited availability of blood products and poor utilization of health care services at the peripheral hospitals. In our tertiary center, with the help of multidisciplinary action to all the near miss cases we can reduce maternal mortality to a great extent.

Structural-functional analyses of textile dye degrading azoreductase, laccase and peroxidase: a comparative in silico study

Background: Textile industry not only plays a vital role in our daily life but also a prominent factor in improving global economy. One of the environmental concern is it releases huge quantities of toxic dyes in the water leading to severe environmental pollution. Bacterial laccase and azoreductase successfully oxidize complex chemical structure of nitrogen group-containing azo dyes. Additionally, the presence of textile dye infuriates bacterial peroxidase to act as a dye degrading enzyme. Our present study deals with three textile dye degrading enzymes laccase, azoreductase, and peroxidase through analyzing their structural and functional properties using standard computational tools. Result: According to the comparative analysis of physicochemical characteristics, it was clear that laccase was mostly made up of basic amino acids whereas azoreductase and peroxidase both comprised of acidic amino acids. Higher aliphatic index ascertained the thermostability of all these three enzymes. Negative GRAVY value of the enzymes confirmed better water interaction of the enzymes. Instability index depicted that compared to laccase and preoxidase, azoreductase was more stable in nature. It was also observed that the three model proteins had more than 90% of total amino acids in the favored region of Ramachandran plot. Functional analysis revealed laccase as multicopper oxidase type enzyme and azoreductase as FMN dependent enzyme, while peroxidase consisted of α-ß barrel with additional haem group. Conclusion: Present study aims to provide knowledge on industrial dye degrading enzymes, choosing the suitable enzyme for industrial set up and to help in understanding the experimental laboratory requirements as well.

Evaluation of anti-nociceptive effect of venlafaxine in experimental animal model of mice

Background: Pain is an unpleasant sensation with varying subjective experience. Its management is always challenging for physicians particularly in case of chronic pain. Chronic pain and depression usually co-exist due to poor quality of life and increase in health care costs posing an individual to suffer from depression. Anti-depressants for pain management are being used successfully using since years. In this study venlafaxine, a newer anti-depressant drug was evaluated for anti-nociceptive activity, tail immersion test an analgesic animal model of albino mice.Methods: Randomly selected albino mice of either sex with reaction time of <6 seconds were included in the study and divided into 7 groups with 6 mice in each group. Grouping was done based on the drug received i.e., venlafaxine 15, 30 and 60 mg/kg, tramadol 10 and 20 mg/kg, control group (normal saline) and combination group venlafaxine 15 mg/kg+tramadol 10 mg/kg. Drugs were administered by intra-peritoneal route.Results: Venlafaxine (30 and 60 mg/kg), tramadol (20 mg/kg) and combination group venlafaxine (15 mg/kg+tramadol 10 mg/kg) has shown significant (p<0.001) increase in tail withdrawal latency compared to control group (normal saline) by tail immersion test. Venlafaxine potentiated anti-nociceptive activity of tramadol on concomitant administration with tramadol. Venlafaxine at 60 mg/kg has comparable anti-nociceptive effect to tramadol at 20 mg/kg.Conclusions: Venlafaxine at doses of 30 and 60 mg/kg is having anti-nociceptive effect, but less potent than tramadol.

Signet ring cell cholangiocarcinoma in a patient previously operated for cholecystectomy: is there any connecting link?

Cholangiocarcinoma are malefic tumours of bile duct. Signet ring cell carcinoma (SRCC) is rare entity. Several risk factors have been attributed to its ethology, the main overriding link between two being chronic inflammation of the bile system. Cholecystectomy has also been a proposed risk factor. This study was undertaken in Department of Pathology at LLRM Medical College, Meerut. A 49 years old female, operated for cholecystectomy 1.5 year back in same hospital, now presented with chief complains of jaundice and abdominal discomfort. The blood chemistry revealed increased total bilirubin (13.7 mg/dl), Alkaline phosphatase (877.6 IU/L), Carbohydrate Antigen (CA) 199(184 U/ml) and Carcinoembryonic antigen (CEA) (14.5 ng/ml). Computed Tomography (CT) showed a stricture in mid Common bile duct (CBD). Excision of stricture was done using retrocholic hepatico-jejunostomy. Tissue was submitted for histopathology. Histopathological assessment showed SRCC. The patient failed to turn up for further management but returned back after a span of time presenting with gross ascites and pallor ultimately leading to death within 12 weeks of diagnosis. This was the first case of SRCC to arise in a patient who had a previous history of cholecystectomy. Whether there is some connecting link between the two is still not clear. Further studies are warranted in this direction to establish cholecystectomy as an etiological factor for cholangiocarcinoma.